Fig. 1 | Scientific Reports

Fig. 1

From: Optimized digital workflow for pathologist-grade evaluation in bleomycin-induced pulmonary fibrosis mouse model

Fig. 1

Prediction of the grade of lung fibrosis. (a) Lung fibrosis was defined as having four grades: none, Grade0; weak, Grade1; moderate, Grade2; severe, Grade3. The grade was defined based on the area of fibrosis spreading. The squares in the top figures indicate the areas of high magnification in the lower section. Bar, 2.5 mm. (b) Overview of workflow for predicting the lung fibrosis grade. Whole slide images (WSIs) were cropped into rectangular images encapsulating the alveolar area and were divided into 1024 × 1024-pixel patches. Each patch was scored according to the area of fibrosis region detected by HALO AI. Next, we generated 5 × 5 tiled images using top 25 scored patches from each WSI. Tiled images were used as inputs for our models to test and evaluate.

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