Fig. 1
From: NLRP3 overexpression exacerbated synovium tissue degeneration in juvenile collagen-induced arthritis
(A) Schematic diagram of animal experiment. (B) In experimental protocols, all rats were assigned to six groups: sham group, CIA group, NC-KD group, KD-NLRP3 group, OE-NC group, and OE-NLRP3 group, with 8 rats in each group. WB: Western blotting; ELISA: Enzyme-linked immunosorbent assay; GSDMD: Gasdermin D; IL-18; Interleukin-18; IL-1β: TInterleukin-1 beta; LC3: Light chain 3β; NF-κB Nuclear Factor Kappa B. (C) Schematic diagram demonstrates the role of NLRP3 in the development of JIA by upregulate the NLRP3–NF-κB axis.
