Fig. 1

Growth rate (GR) analysis of various auristatin molecules in a variety of breast cancer cell lines and a representative non-cancer cell type. GR values for MMAE and MMAD (A) derived from a CellTiter-Glo with a 3-day treatment end point. Summarized GR parameters demonstrating the range of potency (GR50, GEC50) and efficacy (GRmax) across cell lines (B). All data represents mean ± sd, for one experiment with n = 3 biological replicates.