Fig. 6 | Scientific Reports

Fig. 6

From: Glycosylated lysosomal membrane protein promotes tissue repair after spinal cord injury by reducing iron deposition and ferroptosis in microglia

Fig. 6The alt text for this image may have been generated using AI.

Schematic representation the role of Glmp in iron overload and ferroptosis in microglia after SCI. After SCI, iron accumulates around the lesion site and is taken by microglia. This causes damage to mitochondria, resulting in microglial ferroptosis. GLMP plays a vital role in reducing iron overload and preventing ferroptosis in microglia. Knockdown of GLMP in microglia exacerbates iron overload and ferroptosis, leading to neuronal injury and impaired axonal retention.

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