Table 5 Cardiovascular magnetic resonance imaging follow-up.

From: Insights from serial cardiovascular magnetic resonance imaging show early progress in diastolic dysfunction relates to impaired right ventricular deformation

Variable

NCD

follow-up

HFpEF

follow-up

HFpEF IASD

follow-up

NCD

vs. HFpEF

NCD vs.

IASD

HFpEF vs. IASD

Laboratory testing

NTproBNP

81 (65, 138)

225 (86, 344)

267 (190, 431)

0.105

0.022

0.492

Echocardiography

E/e’

10.1 (8.6, 12.0)

9.9 (7.7, 13.1)

9.3 (7.7, 10.5)

0.912

0.368

0.562

TAPSE

23.6 (22.0, 28.5)

24.6 (20.4, 28.0)

26.7 (19.4, 30.9)

0.720

0.864

0.635

Left Ventricle

LV Mass

52.3 (51.4, 62.4)

48.3 (44.5, 54.7)

46.5 (38.3, 60.1)

0.035

0.147

0.635

LV EDV

70.8 (61.3, 86.2)

68.9 (52.3, 80.8)

65.7 (42.8, 81.2)

0.739

0.368

0.562

LV ESV

23.1 (18.0, 29.5)

17.6 (12.8, 28.6)

17.8 (12.2, 28.8)

0.529

0.428

0.958

LV SV

47.5 (44.3, 60.3)

49.3 (40.0, 53.3)

49.3 (29.0, 54.2)

0.796

0.713

0.713

LV EF

70.1 (67.4, 71.7)

72.3 (62.6, 75.8)

67.3 (63.8, 75.0)

0.529

0.635

0.792

FT LV GLS

−24.6 (−21.7, −28.6)

−24.6 (−22.7, −27.3)

−24.3 (−21.7, −25.3)

0.739

0.713

0.263

FT LV GCS

−37.9 (−34.9, −41.8)

−39.4 (−34.6, −41.9)

−39.0 (−35.7, −41.7)

1.000

0.875

0.958

LV LAS rest

14.2 (12.3, 16.5)

14.6 (12.6, 17.0)

12.7 (11.7, 16.9)

0.315

0.792

0.428

LV LAS stress

16.6 (13.7, 20.8)

15.6 (12.7, 19.1)

14.7 (12.8, 18.8)

0.796

0.562

0.958

Septal Native T1

1347 (1294, 1376)

1329 (1304, 1377)

1287 (1064, 1472)

0.968

0.272

0.147

Septal ECV

25.3 (23.6, 27.4)

27.3 (25.7, 29.5)

26.5 (25.6, 27.2)

0.133

0.328

0.263

Left Atrium

FT LA Es

23.5 (19.6, 35.9)

15.6 (12.1, 28.4)

20.9 (12.8, 25.5)

0.218

0.313

0.875

FT LA Ee

11.1 (7.9, 22.3)

8.1 (6.2, 13.6)

9.5 (6.3, 15.4)

0.280

0.368

0.958

FT LA Ea

12.6 (7.5, 17.5)

8.8 (4.7, 14.8)

10.3 (5.0, 13.7)

0.247

0.368

0.958

LA LAS rest

20.8 (17.2, 28.4)

20.0 (8.9, 22.3)

14.1 (11.5, 21.1)

0.353

0.118

0.713

LA LAS stress

26.5 (20.9, 36.8)

19.5 (16.8, 25.1)

15.3 (13.7, 24.0)

0.063

0.042

0.368

Right Ventricle

RV EDV

65.5 (59.2, 85.1)

67.4 (59.2, 75.8)

76.3 (52.5, 100.9)

0.912

0.713

0.492

RV ESV

25.2 (19.1, 33.5)

21.3 (17.4, 24.7)

28.3 (22.3, 41.0)

0.481

0.635

0.181

RV SV

40.8 (39.7, 51.2)

45.0 (41.8, 48.2)

41.0 (32.8, 69.0)

0.393

0.875

0.635

RV EF

65.2 (56.0, 67.1)

68.0 (64.5, 71.4)

61.7 (53.4, 67.8)

0.075

0.713

0.147

RV LAS rest

16.9 (13.9, 20.2)

19.6 (17.7, 25.2)

18.2 (15.3, 19.9)

0.315

0.792

0.428

RV LAS stress

19.2 (10.9, 25.9)

18.6 (13.8, 22.4)

16.1 (7.6, 22.2)

0.912

0.220

0.428

  1. TAPSE: tricuspid annular plane systolic excursion, LV: left ventricular, EDV/ESV: end-diastolic/-systolic volume, SV: stroke volume, EF: ejection fraction, FT: Feature-Tracking, GLS/GCS: Global longitudinal/circumferential strain, LAS: long axis strain, ECV: extracellular volume, LA: left atrium, Es/e/a: reservoir/conduit/booster pump function, RV: right ventricle. Bold p-values indicate statistical significance below 0.05. Volumes are given in ml/m² BSA, mass in g/m² BSA, strain/EF/ECV in %, T1 in ms, NTproBNP in pg/ml and TAPSE in mm.