Fig. 5
Exposure to 100 kHz US has no effect on anxiety as measured by the elevated plus maze (EPM) test. (a and b) Proportion of time spent in the open arms by sham controls and OBX rats during the EPM test conducted after (a) 12 h (CV = 0.46, 0.83, and 0.27 from left to right) or (b) 24 h (CV = 0.25, 0.48, and 0.65 from left to right) with no-sound (yellow) or US (green). (c and d) Total distance traveled during these same EPM tests, (c) 12 h (CV = 0.18, 0.23, and 0.15 from left to right) and (d) 24 h (CV = 0.15, 0.19, and 0.19 from left to right). Group sizes for the 12 h (a and c) exposure: sham rats (n = 7), OBX rats with no-sound (n = 7), and OBX rats exposed to 100 kHz US (n = 6). Group sizes for the 24 h (b and d) exposure: sham rats (n = 12), OBX rats with no-sound (n = 10), and OBX rats exposed to 100 kHz US (n = 10). All data are presented as mean ± standard error of the mean (SEM). *P < 0.05 by one-way ANOVA with post hoc Holm–Sidak multiple comparison tests.
