Table 2 Comparison of positive predictive values (PPV) for fetal chromosomal aneuploidy results between NIPT and expanded NIPT.
Characteristic | Prenatal diagnostic validated by CMA/CS in NIPT | Prenatal diagnostic validated by CMA/CS in expanded NIPT | p | ||||
|---|---|---|---|---|---|---|---|
Positive | Negative | PPV | Positive | Negative | PPV | ||
Total | 311 | 309 | 50.2% | 87 | 97 | 47.28% | 0.02 |
Trisomy 21 | 173 | 31 | 84.80% | 40 | 6 | 86.96% | 0.42 |
Trisomy 18 | 36 | 16 | 69.23% | 12 | 3 | 80.00% | <0.001 |
Trisomy 13 | 10 | 30 | 25.00% | 7 | 13 | 35.00% | 0.42 |
Other autosomal aneuploidies | 7 | 147 | 4.55% | 5 | 52 | 8.77% | 0.24 |
Sex chromosome aneuploidy | 85 | 85 | 50.00% | 23 | 23 | 50.00% | 1 |
