Fig. 3
Enrichment analysis for REST-targeted DEGs. (A) The Venn diagram displayed the overlap between REST target genes and DEGs. The overlapping genes are REST-targeted DEGs. (B) The top 15 results of KEGG analysis for REST-targeted DEGs in DS hiPSC-derived NPCs were shown. The count refers to the gene numbers enriched in these pathways. The larger the number of genes, the bigger the corresponding circle. (C) The biological process clustering enrichment analysis for REST-targeted DEGs in DS hiPSC-derived NPCs. All 1175 GO terms were semantically clustered into 10 categories. On the left is the visualisation of the similarity matrix, where the similarity bar ranges from 0 to 1, indicating the degree of similarity from low to high. Redder colours represent higher similarity values. On the right is the annotation of the clustered GO items in a word cloud.
