Fig. 6

Validation of REST-targeted hub DEGs at the level of gene expression. (A) The expression levels of the 6 REST-targeted hub genes of the GSE185192 training dataset. (B) The expression levels of the 6 REST-target hub genes of the GSE208625 validation dataset. The group comparisons were made using the t-test, with a p-value < 0.05 considered as statistically significant. *P < 0.05, **P < 0.01, ***P < 0.001. ns, no significance; Con, Control; DS, Down syndrome.