Fig. 5
PDE4 inhibitor roflumilast reduce the progression of IDD lesions in rat model. (A) Representative MR images of IDD model and roflumilast-treated IDD model before and after modeling. The orange arrow indicates the needle puncture site. (B) Representative pathological images of intervertebral disc tissue from control, IDD model and roflumilast-treated IDD model stained with safranine and fast green and stained with H&E. (C) MRI degeneration score of control, IDD model and roflumilast-treated IDD model. (D) NP histologic degeneration score of control, IDD model and roflumilast-treated IDD model. Statistical differences between groups were analyzed by two-way ANOVA. The data shown are the means ± SEMs. The biological replicates are 5. * p < 0.05, ** p < 0.01, ***p < 0.001.
