Fig. 2
Extraction of macrophage-specific genes and cell-cell communication. (A) Volcano plot of 482 differentially expressed genes in macrophage clusters. (B) KEGG pathway enrichment analysis of the 482 genes. (C) GO term enrichment analysis of the 482 genes. (D) Protein-protein interaction network for the 482 genes. (E–G) Central nodes identified in the protein interaction network using the EPC, Degree, and MNC topological network methods, respectively. (H–I) Cell-cell communication networks among 6 cell types, with connections colored by communication quantity (H) or strength (I). (J) Specific ligand-receptor interactions within macrophage clusters. (K–M) MHC-II signaling pathway (K), CD99 signaling pathway (L), and ITGB2 signaling pathway (M) in macrophage interactions with other cells.
