Fig. 6 | Scientific Reports

Fig. 6

From: Comprehensive analysis reveals the tumor suppressor role of macrophage signature gene FCER1G in hepatocellular carcinoma

Fig. 6

Bioinformatics analysis of FCER1G. (A) Protein structure of FCER1G from the PDB database. (B) Downregulation of FCER1G protein levels in liver cancer tissues from the CPTAC database. (C) Downregulation of FCER1G transcript levels in liver cancer tissues from the TCGA-LIHC cohort. (D) Abnormal phosphorylation of FCER1G protein in liver cancer tissues from CPTAC phosphoproteomics data. (E) Immunohistochemical detection of FCER1G expression in normal and HCC tissues. (F) Protein interaction network of FCER1G from the STRING database. (G) Mutation analysis of TCGA-LIHC cohort grouped by FCER1G transcript levels. (H) ssGSEA algorithm calculating enrichment scores for each pathway, with Spearman correlation between FCER1G transcript levels and pathway scores.

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