Fig. 1

Identification of ECM-nominated Genes. (A) The scale-free topology criterion for TCGA-STAD requires a soft threshold power (β) of option 7. (B) Gene Co-expression Module Analysis recognized by cluster dendrogram. (C) Relevancy analysis of modules with StromalScore, ImmuneScore and ESTIMATEScore. (D) Venn diagram of the 1,026 ECM genes and 937 ECM-associated genes from WGCNA. (E) Forest plots presenting univariate Cox regression analyses of candidate ECM genes as independent prognostic factors. (F, G) Enrichment analysis of the candidate ECM genes by virtue of KEGG Enrichment Analysis (F) and Metascape database (G), respectively.