Fig. 4

Low expression of COX11 in tumor tissues of patients with T2DM-CRC co-morbidities was significantly associated with poor prognosis. (A) Expression of COX11 in tumor tissues and normal tissues of patients with CRC. (B,C). Proteomic data and HPA databases confirmed that the relative expression level of COX11 protein is significantly up-regulated in CRC tumor tissues. (D) External datasets confirmed at the transcriptional level that COX11 is highly expressed in tumor tissues and low expressed in T2DM pancreatic islets. (E) COX11 was significantly correlated with pathological stage and N stage, and not significantly correlated with MSI stability and T and M stage. tissues and low expression in T2DM islets. (F–H). Low expression of COX11 (at transcriptional level) in TCGA-COREAD(F)/TCGA-COAD(G)/TCGA-READ(H) is suggestive of poor prognosis. (I) COX11 survival curves based on CPTAC data (protein level). (J) COX11 survival curves obtained based on HPA (transcript level) database analysis.