Table 2 Weighted logistic regression (OR, 95%CI; P) of urinary phytoestrogens over accelerated-aging in the NHANES 1999–2010 sample.

From: Elevated urinary phytoestrogens are associated with delayed biological aging: a cross-sectional analysis of NHANES data

  

Model 1

Model 2

Model 3

β (95% CI)

P

β (95% CI)

P

β (95% CI)

P

Advanced-KDM

Total phytoestrogen

− 0.67 (− 0.81, − 0.53)

< 0.001

− 0.41 (− 0.55, − 0.27)

< 0.001

− 0.42 (− 0.55, − 0.28)

< 0.001

 

Isoflavones

− 0.19 (− 0.29, − 0.09)

< 0.001

− 0.12 (− 0.22, − 0.03)

0.01

− 0.12 (− 0.21, − 0.03)

0.007

 

Enterolignans

− 0.53 (− 0.64, − 0.42)

< 0.001

− 0.31 (− 0.42, − 0.20)

< 0.001

− 0.32 (− 0.42, − 0.21)

< 0.001

Advanced-PA

Total phytoestrogen

− 0.54 (− 0.64, − 0.44)

< 0.001

− 0.30 (− 0.40, − 0.20)

< 0.001

− 0.33 (− 0.43, − 0.24)

< 0.001

 

Isoflavones

− 0.15 (− 0.23, − 0.08)

< 0.001

− 0.10 (− 0.17, − 0.04)

0.002

− 0.12 (− 0.18, − 0.05)

< 0.001

 

Enterolignans

− 0.44 (− 0.52, − 0.36)

< 0.001

− 0.23 (− 0.31, − 0.15)

< 0.001

− 0.25 (− 0.33, − 0.17)

< 0.001

Advanced-HD

Total phytoestrogen

− 0.06 (− 0.08, − 0.04)

< 0.001

− 0.03 (− 0.05, − 0.01)

0.002

− 0.04 (− 0.05, − 0.02)

< 0.001

 

Isoflavones

− 0.01 (− 0.03, 0.00)

0.08

− 0.01 (− 0.02, 0.01)

0.29

− 0.01 (− 0.02, 0.00)

0.15

 

Enterolignans

− 0.05 (− 0.06, − 0.04)

< 0.001

− 0.03 (− 0.04, − 0.01)

0.001

− 0.03 (− 0.04, − 0.02)

< 0.001

  1. Model 1 adjusted for sex (men/women), ethnicity (non-Hispanic whites, non-Hispanic Blacks, Mexican Americans, and others), education levels (less than high school graduate, high school graduate to some college, college graduate or higher), and poverty income ratio; Model 2 further adjusted for BMI (kg/m2), cigarette smoking (non-smoker, former smoker, current smoker), alcohol consumption (non-drinker, former drinker, moderate drinker, and heavy drinker), physical activity levels (MET-hrs/day) and HEI-2015 based on model 1; Model 3 was further adjusted for history of chronic diseases (hypertension, high cholesterol, chronic bronchitis, hepatopathy, kidney disease, diabetes, cardiovascular disease, stroke, and cancer) (yes and not) based on model 2. KDM, Klemera-Doubal method biological age; PA, phenotypic age; HD, homeostatic dysregulation.
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