Fig. 6
From: The liver proteome of individuals with a natural UGT2B17 complete deficiency
Activation of immune-related pathways in livers of UGT2B17-deficient individuals and summary of findings. (A) Neutrophil activation is characterized by the release of granule proteins at sites of cell damage or infection. Several proteins key to neutrophil activation and ER-associated degradation (ERAD) of misfolded damaged proteins were more abundant in UGT2B17-deficient livers. Note that this schematic representation is simplified from a highly complex process, to solely highlight the role of differentially expressed proteins in the context of immune pathways. Created with BioRender.com. (B) Differential abundance of NADPH oxidase 2 (NOX2) and neutrophil granule proteins. MMP9: matrix metalloproteinase 9; LYZ: lysozyme; DEFA1: defensin 1; PSAP: prosaposin; CTSS: cathepsin S in UGT2B17 proficient (+) and deficient (−) individuals. In boxplots, sex of liver donors is indicated (blue dots, males; red dots, females), the line represents median expression, “ + ” represents mean expression, and whiskers the range of values. *P < 0.05, **P < 0.01. (C) Graphical summary of findings.
