Table 3 Clinical findings in affected dogs.
From: GTPBP2 in-frame deletion in canine model with non-syndromic progressive retinal atrophy
Clinical findings | LR3 | LR5 | LR8 |
|---|---|---|---|
Retinal degeneration | Early onset | Early onset | Early onset |
2ry cataracts | Late, after advanced retinal degeneration | Late, after advanced retinal degeneration | Late, after advanced retinal degeneration |
Mentation | Smart, easily trained | Smart, easily trained, good memory; low energy level | Easily trained, smart, good memory; low energy level |
Neurologic abnormalities (by clinical veterinarian) | Absent | Absent | Absent |
Neurologic abnormalities (by DACVIM-Neurology) | ND | ND | Normal except absent PLR |
Addison’s disease | Glucocorticoid dependent | Glucocorticoid and mineralocorticoid dependent | Normal |
Diabetes mellitus | Present-died 2ry to hypoglycemia | Absent | Absent |
Appendicular skeleton | Normal | Normal | normal |
Arthritis/joint disease | In house hip ratings: good/very good; none present prior to death | Lame at 9 m: RF shoulder/elbow. Rads of LF/RF elbows normal mainly elbows, but also the knees though less severe | Absent in house hip ratings: good/very good |
Hair coat | Normal | Normal | Normal |
Allergies/GI | NR | chicken; inflammatory bowl disease | Normal |
