Fig. 2
From: A population based study to analyse amyotrophic lateral sclerosis as a multi-step process

Log incidence vs. log age in the ALS population province of Palermo, Sicily Island geographical area. The graph shows a good fit with a straight line with r2 = 0.93 consistent with the multistep model. The slope estimate is 5 (CI 95% 2.51–7.60; p = 0.008), suggesting that six steps are needed to trigger the onset of the disease.