Fig. 2
Genome-wide significant differences in site-specific DNA methylation when comparing violence exposure groups and controls. Forest plots show DNAm levels for loci that reached genome-wide significance (p-value < 6.5 × 10–8) in both robust regression and GEE EWAS when comparing germline exposure to violence (a,b) and direct exposure to violence (c,d) to controls. Panels (a) and (c) are forest plots of the beta-value differences between all exposures relative to controls for all significant DMPs. The dots indicate the median difference and bars represent the 95% confidence intervals. Panels (b) and (d) are boxplots of the distribution of beta-values by violence exposure category; the middle line indicates the median, the box covers the interquartile range, and dots indicate observed beta-values. Exposure types are color coded: red = direct exposure, green = prenatal exposure, blue = germline exposure, and yellow = no exposure.
