Table 2 Comparison of cTMB and ITH level for the same raw sequencing data analyzed by Riaz versus Clonal Neoantigen pipeline.

From: Exome sequencing shows same pattern of clonal tumor mutational burden, intratumor heterogenicity and clonal neoantigen between autologous tumor and Vigil product

Patient ID

Sex

Group

Riaz Clonal Muts (> 0.85 CCF)

Riaz Total Muts

Riaz ITH

Riaz cTMB

Clonal Neoantigen Pipeline Total Muts

Clonal Neoantigen Pipeline ITH

Clonal Neoantigen Pipeline cTMB

Clonal Neoantigen Pipeline cNEO

Pt18

Male

CR

212

212

0.000

5.470

240

0.079

4.381

8.841

Pt3

Male

CR

166

176

0.057

4.283

207

0.208

3.251

4.698

Pt30

Female

CR

35

65

0.462

0.903

93

0.634

0.674

0.714

Pt44

Male

CR

350

358

0.022

9.031

374

0.214

5.828

12.726

Pt7

Male

CR

1463

1480

0.011

37.749

1354

0.185

21.865

36.177

Pt72

Female

CR

387

407

0.049

9.986

413

0.380

5.075

13.321

Pt94

Male

CR

395

395

0.000

10.192

280

0.139

4.777

11.616

Pt11

Female

PD

83

95

0.126

2.142

133

0.323

1.784

3.548

Pt25

Male

PD

72

93

0.226

1.858

111

0.505

1.090

2.458

Pt28

Female

PD

14

42

0.667

0.361

72

0.681

0.456

1.051

Pt5

Female

PD

22

49

0.551

0.568

144

0.764

0.674

1.289

Pt74

Male

PD

37

42

0.119

0.955

44

0.182

0.714

1.586

Pt8

Male

PD

76

86

0.116

1.961

87

0.126

1.507

2.617

Pt84

Female

PD

3

10

0.700

0.077

19

0.526

0.178

0.456

Mean

236.8

250.7

0.222

6.110

255.1

0.353

3.732

7.221

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