Table 1 Clinicopathologic characteristics of all the patients.

From: Prognostic model for log odds of negative lymph node in locally advanced rectal cancer via interpretable machine learning

Characteristics

Total (n = 820)

Test (n = 246)

Train (n = 574)

P value

LONT (Mean ± SD)

0.65 ± 0.32

0.65 ± 0.35

0.64 ± 0.32

0.681

Tumor size (Mean ± SD), (cm)

2.70 ± 1.28

2.82 ± 1.31

2.65 ± 1.26

0.081

PLN count (Mean ± SD)

0.71 ± 2.34

0.74 ± 2.79

0.70 ± 2.12

0.840

ELN count (Mean ± SD)

12.71 ± 5.79

12.52 ± 6.20

12.79 ± 5.60

0.531

NLN count (Mean ± SD)

12.00 ± 5.61

11.78 ± 5.95

12.09 ± 5.46

0.465

Distance from the anal verge count (Mean ± SD), (cm)

6.48 ± 2.44

6.49 ± 2.54

6.48 ± 2.40

0.964

Postoperative hospital stay count (Mean ± SD), (day)

8.72 ± 5.30

9.07 ± 6.49

8.57 ± 4.69

0.217

Age count (Mean ± SD), (year)

55.98 ± 11.23

56.67 ± 10.59

55.68 ± 11.49

0.244

Sex (%)

   

0.401

Female

274 (33.41)

77 (31.30)

197 (34.32)

 

Male

546 (66.59)

169 (68.70)

377 (65.68)

 

ASA score, n(%)

   

0.311

I

619 (75.49)

178 (72.36)

441 (76.83)

 

II

189 (23.05)

65 (26.42)

124 (21.60)

 

III

12 (1.46)

3 (1.22)

9 (1.57)

 

cT stage, n(%)

   

0.367

cT1

1 (0.12)

1 (0.41)

0 (0.00)

 

cT2

12 (1.46)

5 (2.03)

7 (1.22)

 

cT3

302 (36.83)

91 (36.99)

211 (36.76)

 

cT4

505 (61.59)

149 (60.57)

356 (62.02)

 

cN stage, n(%)

   

0.393

cN0

71 (8.66)

19 (7.72)

52 (9.06)

 

cN1

8 (0.98)

4 (1.63)

4 (0.70)

 

cN2

741 (90.37)

223 (90.65)

518 (90.24)

 

ypTNM stage (8th AJCC), n(%)

   

0.345

pCR

171 (20.85)

60 (24.39)

111 (19.34)

 

I

208 (25.37)

57 (23.17)

151 (26.31)

 

II

232 (28.29)

71 (28.86)

161 (28.05)

 

III

209 (25.49)

58 (23.58)

151 (26.31)

 

pT stage

   

0.089

T0

181 (22.07)

64 (26.02)

117 (20.38)

 

T1

58 (7.07)

15 (6.10)

43 (7.49)

 

T2

197 (24.02)

52 (21.14)

145 (25.26)

 

T3

356 (43.41)

102 (41.46)

254 (44.25)

 

T4

28 (3.41)

13 (5.28)

15 (2.61)

 

pN stage

   

0.639

N0

612 (74.63)

189 (76.83)

423 (73.69)

 

N1

168 (20.49)

46 (18.70)

122 (21.25)

 

N2

40 (4.88)

11 (4.47)

29 (5.05)

 

APR, n(%)

   

0.736

No

721 (88.03)

218 (88.62)

503 (87.78)

 

Yes

98 (11.97)

28 (11.38)

70 (12.22)

 

Neural invasion

   

0.441

No

783 (95.49)

237 (96.34)

546 (95.12)

 

Yes

37 (4.51)

9 (3.66)

28 (4.88)

 

Lymphovascular invasion

   

0.164

No

794 (96.83)

235 (95.53)

559 (97.39)

 

Yes

26 (3.17)

11 (4.47)

15 (2.61)

 

Postoperative complication

   

0.607

No

698 (85.12)

207 (84.15)

491 (85.54)

 

Yes

122 (14.88)

39 (15.85)

83 (14.46)

 

Radiotherapy complication

   

0.767

No

564 (68.78)

171 (69.51)

393 (68.47)

 

Yes

256 (31.22)

75 (30.49)

181 (31.53)

 

TRG grade, n(%)

   

0.052

0

171 (20.85)

60 (24.39)

111(19.34)

 

1

278 (33.90)

89 (36.18)

189 (32.93)

 

2

312 (38.05)

77 (31.30)

235 (40.94)

 

3

59 (7.20)

20 (8.13)

39 (6.79)

 
  1. ELNs examined lymph nodes, NLNs negative lymph nodes, PLNs positive lymph nodes, IQR interquartile range, LONT log odds of negative lymph nodes/T stage, ASA American Society of Anesthesiologists, TRG grade tumor regression grade, APR abdominoperineal resection.