Table 3 Univariate and multivariable analysis of disease-free survival.

From: Prognostic model for log odds of negative lymph node in locally advanced rectal cancer via interpretable machine learning

Variable

Univariate analysis

Multivariate analysis

HR (95%CI) P-value

HR (95%CI) P-value

Mean, age (year)

0.991(0.978–1.005)

0.198

  

Mean, LONT

0.208(0.129–0.336)

< 0.001

0.386(0.212–0.701)

0.002

Mean, NLNs

0.968(0.940–0.996)

0.024

-

-

Mean, interval time between NCRT and surgery (day)

1.015(0.996–1.034)

0.124

  

Mean, postoperative hospital stay(day)

1.018(0.993–1.043)

0.157

  

Mean, tumor size(cm)

1.343(1.218–1.482)

< 0.001

1.202(1.079–1.340)

0.001

Mean, distance from the anal verge(cm)

0.905(0.847–0.966)

0.003

0.899(0.843–0.958)

0.001

Sex

 

0.495

  

Female

1

   

Male

0.896(0.653–1.228)

   

ASA score, n(%)

 

0.943

  

I

1

   

II

0.975(0.678-1.400)

0.889

  

III

1.193(0.380–3.749)

0.762

  

ypTNM stage (8th AJCC), n(%)

 

< 0.001

 

< 0.001

pCR

1

 

1

 

I

1.272(0.647–2.501)

0.486

2.744(0.583–12.906)

0.201

II

3.121(1.734–5.619)

< 0.001

4.809(1.062–21.770)

0.042

III

5.788(3.277–10.223)

< 0.001

8.101(1.860-32.295)

0.005

pT stage

 

< 0.001

 

-

T0

1

 

-

 

T1

0.695(0.235–2.053)

0.510

-

-

T2

1.711(0.960–3.047)

0.068

-

-

T3

3.536(2.147–5.824)

< 0.001

-

-

T4

1.958(0.727–5.274)

0.184

-

-

pN stage

 

< 0.001

 

-

N0

1

 

-

 

N1

2.965(2.139–4.109)

< 0.001

-

-

N2

3.832(2.308–6.363)

< 0.001

-

-

APR, n(%)

 

0.278

  

No

1

   

Yes

1.245(0.838–1.851)

   

Radiotherapy complication

 

0.018

  

No

1

   

Yes

1.450(1.065–1.976)

   

Neural invasion

 

0.021

 

0.587

No

1

 

1

 

Yes

2.004(1.113–3.609)

 

0.835(0.436-1.600)

 

Postoperative complication

 

0.269

  

No

1

   

Yes

1.249(0.842–1.854)

   

Lymphovascular invasion

 

0.035

 

0.689

No

1

 

1

 

Yes

2.059(1.052–4.031)

 

1.155(0.570–2.342)

 

TRG grade(%)

 

< 0.001

 

0.056

0

1

 

1

 

1

1.866(1.053–3.306)

0.033

0.244(0.056–1.067)

0.061

2

3.629(2.133–6.175)

< 0.001

0.382(0.089–1.646)

0.197

3

3.875(1.957–7.670)

< 0.001

0.327(0.069–1.541)

0.158

pre-CEA

 

0.237

  

≤ 5ug/L

1

   

>5ug/L

1.218(0.878–1.690)

   

pre-CA199

 

0.143

  

≤ 37U/ml

1

   

>37U/ml

1.314(0.912–1.893)

   

post-CEA

 

< 0.001

 

0.060

≤ 5ug/L

1

 

1

 

>5ug/L

2.056(1.422–2.974)

 

1.707(1.167–2.479)

 

post-CA199

 

0.831

  

≤ 37U/ml

1

   

>37U/ml

0.944(0.555–1.604)

   
  1. Significant values are given in bold.
  2. ELNs examined lymph nodes, NLNs negative lymph nodes, PLNs positive lymph nodes, IQR interquartile range, LONT log odds of negative lymph nodes/T stage, ASA American Society of Anesthesiologists, TRG grade tumor regression grade, APR abdominoperineal resection.
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