Table 6 Recent studies on intracranial epidermoids since 2000 (n > 25).

From: Long term management of intracranial epidermoids balancing extent of resection and functional preservation in a 20 year institutional experience

Authors & years

No. of cases

Location

(No of. cases)

Methodology

Follow-up period

(Mean)

EOR (% of Patients)

Neurological functional Outcome (direct postop)

Neurological functional Outcome in follow-up (compared to direct postop)

Endoscopic assistance operations (%)

Recurrence rate

Kobata et al., 200224

30

CPA (30)

Retrospective Analysis

138

mos

TR (57%)

-ND

-ND

-ND

Crude recurrence free (90%)*

Akar et al., 200342

28

CPA (17), 4th V/FM (3), sylvian fissure (4), occipital lobe (2), lateral ventricle (1), & intradiploic area (1)

Retrospective Analysis

72

mos

Total/radical subtotal (75%), subtotal (25%)

-ND

-New CN deficits: 46.4%

-ND

-ND

Crude recurrence free (93%)*

Gopalakrishnan et al., 201428

50

CPA (37), 4th Ventricle (13)

Retrospective Analysis

111

mos

TR 62%, STR 38%

-ND

-ND

-ND

5-yr recurrence free:

-TR: 91%

-STR: 7%

Lynch et al., 201443

29

CPA (13) & parasellar (6), cerebellar (5), temporal (5), & frontal (4) areas

Retrospective Analysis

86

mos‡

GTR (73%) & STR

(27%)‡

-ND

-ND

-ND

-ND

Aboud et al., 201518

38

Primary lesions: CPA (18), prepontine cistern (4), suprasellar (2), & MF (2)

Recurrent lesions: CPA (6), suprasellar region (3), prepontine cistern (2), & parasellar region (1)

Retrospective Analysis

56.8

mos

GTR (73% of those w/

primary lesion & 17%

w/ recurrence)

-ND

-New CN deficits: 45.6%, in recurrence group: 58%

-ND

-Overall: 28.2%

Crude recurrence-free (85% of those w/ primary tumor & 58% w/ recurrence) †

Rehman et al., 201844

38

CPA (18), (frontal lobe [4], temporal lobe [9], & temporal & parietal lobes w/ CS [1]), & suprasellar region (6)

Retrospective Analysis

-ND

-ND

-ND

-ND

-ND

-ND

Vernon et al. 202020

139

CPA (139)

Retrospective Analysis

27

mos

TR 67%, NTR 3%, PR 2%

-ND

-New CN deficits: 41%

-ND

-Development of the new CN deficits:

Better: 78% Stable: 20%

Worse: 2%

-Overall: 40%

2.5-yr recurrence free: 85%

Hasegawa et al. 20228

63

Posterior fossa (33), lobar/interhemispheric location (11), combined supratentorial & infratentorial area (11), Middle Fossa 3 & pineal region (5)

Retrospective Analysis

88.7

mos

GTR 20%, NTR 24% STR 35% & PR 22%

-ND

-New CN deficits: 31%

-ND

-ND

5-yr recurrence free (66%)

Present Study

66

CPA and prepontine (49), Supratentorial (9). 4th Ventricle (7)

Retrospective Analysis

82.02 mos

TR 61%, NTR 27.6% STR 10.7%

-Better: 11.9%

-Stable: 50%

-Worse: 10.3%

- New CN deficits: 27.7%

-Better: 36.4%

-Stable: 51.1%

-Worse: 12.4%

-Overall: 33.8%

-CPA and prepontine region:36.7%,

Supratentorial: 33.3%, 4th Ventricle: 14.2%

5-yr recurrence free:

TR: 95%

NTR: 45%

STR 30%

  1. ND = no data. GTR = gross total resection. NTR = near total resection. STR = subtotal resection. PR = partial resection. TR = total resection. CN = cranial nerves. * A detailed definition of recurrence was not provided. † Recurrence was defined as progressive symptoms with lesion enlargement. ‡ Data included patients with epidermoid and dermoid lesions.