Table 1 One-sample mendelian randomisation results.

From: Investigating whether smoking and alcohol behaviours influence risk of type 2 diabetes using a Mendelian randomisation study

  

N

Main analysis

Adjusting for chip1

OR or effect (95% CI)

p-value

OR or effect (95% CI)

p-value

T2D

Excluding participants with type 1 diabetes2

266,005

1.71 (1.24 to 2.36)

1.30 × 10−09

1.70 (1.23 to 2.35)

1.30 × 10− 09

HbA1c

Including participants with diabetes2

253,995

−0.02 (−0.08 to 0.03)

0.43

−0.02 (−0.08 to 0.03)

0.40

HbA1c

Excluding participants with diabetes2

242,412

−0.07 (−0.11 to −0.02)

0.002

−0.07 (−0.11 to −0.02)

0.002

  1. Results are the odds ratio (OR) for type 2 diabetes per 1 SD higher log-transformed drinks per week or the difference in mean SD of log transformed HbA1c (mmol/mol) per 1 SD higher log-transformed drinks per week. 1We ran additional sensitivity analyses adjusting for genotyping chip which is confounded with being in the UK biobank lung exome variant evaluation (BiLEVE). 2Exclusion criteria for diabetes was based on having possible or probable type 1 or type 2 diabetes as determined by the Eastwood algorithm or those with HbA1c \(\:\ge\:\)6.5%.
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