Fig. 3 | Scientific Reports

Fig. 3

From: Development and synthesis of diffractaic acid analogs as potent inhibitors of colorectal cancer stem cell traits

Fig. 3

Compound TU3 suppress spheroid formation in CSC221 and CaCo2 cell lines in a dose-dependent manner. Representative images of spheroid formation by CSC221 (A) and CaCo2 (B) cells treated with TU3 at 10 μM concentration for 10–14 days, and quantitative analysis of the number of spheroids formed following each treatment. Flow cytometric analysis of cell cycle distribution. CSC221 (C) and CaCo2 (D) cells were treated with indicated concentrations of TU3 for 48 h incubation. Data represent the mean ± SD, *p < 0.05; **p < 0.01; ***p < 0.001.

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