Table 2 Top 30 unique transcripts by P value with increased expression in biopsies with endoscopic Mayo subcore >1 vs. ≤1 (N = 128 biopsies).
From: Relating the molecular phenotype of ulcerative colitis to the clinical course
P value | Adjusted P value | Gene Symbol | Gene Name | Expression in biopsies | Cellular Expression in Colon tissue per Human Protein Atlasa | ||
|---|---|---|---|---|---|---|---|
Mayo > 1 | Mayo ≤ 1 | Control | |||||
4.61 × 10−16 | 2.28 × 10−11 | CDC25B* | Cell division cycle 25B | 617 | 353 | 292 | colonocytes, T cells, B cells |
3.40 × 10−14 | 4.99 × 10−10 | CHI3L1* | Chitinase 3-like 1 | 1125 | 106 | 47 | NA |
4.03 × 10−14 | 4.99 × 10−10 | VWF* | von Willebrand factor | 549 | 228 | 180 | Granulocytes |
1.65 × 10−13 | 1.25 × 10−9 | ZBP1* | Z-DNA binding protein 1 | 172 | 74 | 63 | Colonocytes |
1.77 × 10−13 | 1.25 × 10−9 | CFB* | Complement factor B | 1861 | 774 | 462 | NA |
2.61 × 10−13 | 1.38 × 10−9 | COL18A1* | Collagen, type XVIII, alpha 1 | 287 | 139 | 126 | Granulocytes |
3.33 × 10−13 | 1.38 × 10−9 | TRAM2* | Translocation associated membrane protein 2 | 981 | 665 | 630 | Intestinal endocrine cells, undifferentiated cells, mucus-secreting cells, B cells, colonocytes |
3.36 × 10−13 | 1.38 × 10−9 | FER1L4* | Fer-1-like 4 (C. elegans) pseudogene | 138 | 66 | 76 | NA |
3.90 × 10−13 | 1.39 × 10−9 | LOC100130872* | Uncharacterized LOC100130872 | 1252 | 558 | 529 | NA |
3.93 × 10−13 | 1.39 × 10−9 | PIM2* | Pim-2 oncogene | 913 | 371 | 330 | B cells, undifferentiated cells, T cells, intestinal endocrine cells |
4.28 × 10−13 | 1.41 × 10−9 | LOXL2* | Lysyl oxidase-like 2 | 395 | 200 | 139 | B cells, undifferentiated cells |
4.90 × 10−13 | 1.43 × 10−9 | OLFML2B* | Olfactomedin-like 2B | 177 | 74 | 71 | B cells |
5.28 × 10−13 | 1.45 × 10−9 | TGM2* | Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 127 | 63 | 64 | Colonocytes |
5.57 × 10−13 | 1.45 × 10−9 | FCRL5* | Fc receptor-like 5 | 300 | 103 | 110 | B cells, undifferentiated cells |
7.66 × 10−13 | 1.90 × 10−9 | NRD1* | Nardilysin (N-arginine dibasic convertase) | 621 | 508 | 489 | NA |
1.36 × 10−12 | 2.61 × 10−9 | CTHRC1* | Collagen triple helix repeat containing 1 | 599 | 166 | 149 | Undifferentiated cells |
1.38 × 10−12 | 2.61 × 10−9 | RPS6KA2* | Ribosomal protein S6 kinase, 90 kDa, polypeptide 2 | 259 | 157 | 143 | Colonocytes, intestinal endocrine cells, undifferentiated cells, mucus-secreting cells |
2.02 × 10−12 | 3.44 × 10−9 | SERPING1* | Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | 418 | 210 | 202 | NA |
2.15 × 10−12 | 3.52 × 10−9 | ELL2* | Elongation factor, RNA polymerase II, 2 | 576 | 277 | 262 | Granulocytes, intestinal endocrine cells, B cells, colonocytes |
2.23 × 10−12 | 3.52 × 10−9 | COL4A1* | Collagen, type IV, alpha 1 | 964 | 398 | 302 | Undifferentiated cells, mucus-secreting cells |
2.35 × 10−12 | 3.52 × 10−9 | ODF3B | Outer dense fiber of sperm tails 3B | 235 | 161 | 141 | B cells, colonocytes, intestinal endocrine cells, undifferentiated cells, mucus-secreting cells |
2.90 × 10−12 | 4.10 × 10−9 | IFITM2 | Interferon induced transmembrane protein 2 | 1480 | 884 | 769 | T cells, granulocytes, B cells, undifferentiated cells |
2.99 × 10−12 | 4.11 × 10−9 | MZB1 | Marginal zone B and B1 cell-specific protein | 1987 | 733 | 779 | Undifferentiated cells |
3.15 × 10−12 | 4.21 × 10−9 | KYNU | Kynureninase | 169 | 93 | 85 | B cells, undifferentiated cells, colonocytes |
3.51 × 10−12 | 4.26 × 10−9 | GJA4 | Gap junction protein, alpha 4, 37 kDa | 77 | 48 | 48 | Intestinal endocrine cells |
3.67 × 10−12 | 4.26 × 10−9 | CPNE5 | Copine V | 489 | 321 | 357 | B cells, Paneth cells, colonocytes, undifferentiated cells, intestinal endocrine cells |
4.00 × 10−12 | 4.26 × 10−9 | RNF213 | Ring finger protein 213 | 1500 | 951 | 863 | Colonocytes, T cells, B cells, undifferentiated cells |
4.05 × 10−12 | 4.26 × 10−9 | PREB | Prolactin regulatory element binding | 326 | 255 | 241 | Granulocytes, mucus-secreting cells, T cells, undifferentiated cells |
4.61 × 10−12 | 4.56 × 10−9 | MLKL | Mixed lineage kinase domain-like | 456 | 280 | 246 | Granulocytes, undifferentiated cells |
4.78 × 10−12 | 4.59 × 10−9 | IGFBP5 | Insulin-like growth factor binding protein 5 | 2126 | 799 | 527 | Undifferentiated cells |
