Fig. 4 | Scientific Reports

Fig. 4

From: Discovery and functional characterization of canine PD-L1-targeted antibodies for evaluating antitumor efficacy in a canine osteosarcoma xenograft model

Fig. 4

Inhibitory efficacy of canine anti-PD-L1 antibody candidates against canine PD-L1 in vitro. (A) Canine PD-L1-specific IgG candidates were co-cultured with two different sets of 5 × 104 canine PBMCs. Each candidate was treated with 0, 5, 10, and 20 μg/ml, incubated for 3 days, and the proliferation was measured using CCK8. (B) The inhibitory efficacy of canine anti-PD-L1 antibodies validated through a Canine PD-1/PD-L1 Blockade Bioassay.

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