Table 2 Associations of De Ritis with poor functional outcomes at discharge and 3 months follow-up.

From: Relationship between De Ritis and clinical outcomes in patients with aneurysmal subarachnoid hemorrhage: Insights from the LongTEAM registry

Outcomes

Totaln = 1098

Quartiles of De Ritis

P for trend

Binary classification

Q1n = 271

Q2n = 272

Q3n = 280

Q4n = 275

 < 1

n = 360

 ≥ 1

n = 738

Death at discharge

 n (%)

17 (1.5)

0 (0)

2 (0.7)

4 (1.4)

11 (4.0)

 

2 (0.6)

15 (2.0)

 Unadjusted

 

Ref

-

-

-

 < 0.001

Ref

3.729 (0.848–16.396)

 Model 1

 

Ref

-

-

-

 < 0.001

Ref

1.184 (0.904–1.552)

 Model 2

 

Ref

-

-

-

0.018

Ref

1.903 (0.374–9.674)

 Model 3

 

Ref

-

-

-

0.018

Ref

1.912 (0.358–10.203)

mRS 3–6 at discharge

 n (%)

446 (40.6)

100 (36.9)

93 (34.2)

129 (46.1)

124 (45.1)

 

127 (35.3)

319 (43.2)

 Unadjusted

 

Ref

0.888 (0.625–1.263)

1.461 (1.039–2.054)

1.404 (0.997–1.978)

0.010

Ref

1.382 (1.065–1.792)

 Model 1

 

Ref

0.782 (0.545–1.124)

1.181 (0.828–1.685)

1.187 (0.832–1.693)

0.112

Ref

1.354 (0.973–1.885)

 Model 2

 

Ref

0.646 (0.424–0.983)

1.012 (0.671–1.526)

0.761 (0.497–1.165)

0.505

Ref

0.900 (0.654–1.237)

 Model 3

 

Ref

0.623 (0.408–0.951)

0.993 (0.656–1.502)

0.747 (0.483–1.155)

0.482

Ref

0.884 (0.641–1.220)

mRS 4–6 at discharge

 n (%)

234 (21.3)

49 (18.1)

43 (15.8)

68 (24.3)

74 (26.9)

 

61 (16.9)

173 (23.4)

 Unadjusted

 

Ref

0.851 (0.543–1.333)

1.453 (0.962–2.196)

1.668 (1.109–2.509)

0.002

Ref

1.468 (1.064–2.027)

 Model 1

 

Ref

0.809 (0.513–1.276)

1.311 (0.857–2.006)

1.537 (1.012–2.336)

0.008

Ref

1.354 (0.973–1.885)

 Model 2

 

Ref

0.596 (0.348–1.021)

1.043 (0.631–1.724)

0.893 (0.536–1.489)

0.828

Ref

0.954 (0.640–1.423)

 Model 3

 

Ref

0.547 (0.318–0.943)

1.006 (0.606–1.670)

0.819 (0.484–1.385)

0.991

Ref

0.895 (0.597–1.343)

Death at 90 days

 n (%)

28 (2.6)

1 (0.4)

3 (1.1)

7 (2.5)

17 (6.2)

 

3 (0.8)

25 (3.4)

 Unadjusted

 

Ref

3.011 (0.311–29.130)

6.923 (0.846–56.650)

17.791 (2.351–134.649)

 < 0.001

Ref

4.190 (1.257–13.971)

 Model 1

 

Ref

2.744 (0.283–26.650)

5.871 (0.709–48.596)

15.639 (2.051–119.219)

 < 0.001

Ref

3.697 (1.098–12.447)

 Model 2

 

Ref

1.878 (0.182–19.332)

4.224 (0.487–36.609)

7.230 (0.895–58.368)

0.008

Ref

2.004 (0.556–7.227)

 Model 3

 

Ref

1.915 (0.183–20.006)

4.317 (0.491–37.954)

6.679 (0.812–54.919)

0.016

Ref

1.787 (0.487–6.560)

mRS 3–6 at 90 days

 n (%)

210 (19.1)

33 (12.2)

45 (16.5)

62 (22.1)

70 (25.5)

 

49 (13.6)

161 (21.8)

 Unadjusted

 

Ref

1.430 (0.881–2.321)

2.051 (1.294–3.251)

2.463 (1.564–3.878)

 < 0.001

Ref

1.780 (1.256–2.521)

 Model 1

 

Ref

1.260 (0.769–2.067)

1.608 (0.999–2.588)

2.045 (1.282–3.261)

 < 0.001

Ref

1.486 (1.038–2.128)

 Model 2

 

Ref

1.116 (0.645–1.931)

1.436 (0.848–2.432)

1.401 (0.826–2.378)

0.180

Ref

1.175 (0.782–1.766)

 Model 3

 

Ref

1.035 (0.594–1.803)

1.371 (0.805–2.335)

1.223 (0.710–2.109)

0.398

Ref

1.072 (0.708–1.624)

mRS 4–6 at 90 days

 n (%)

131 (11.9)

15 (5.5)

29 (10.7)

40 (14.3)

47 (17.1)

 

27 (7.5)

104 (14.1)

 Unadjusted

 

Ref

2.037 (1.066–3.892)

2.844 (1.532–5.282)

3.518 (1.915–6.462)

 < 0.001

Ref

2.032 (1.304–3.167)

 Model 1

 

Ref

1.737 (0.901–3.352)

2.101 (1.115–3.959)

2.792 (1.502–5.190)

 < 0.001

Ref

1.627 (1.032–2.564)

 Model 2

 

Ref

1.537 (0.759–3.112)

1.851 (0.934–3.668)

1.867 (0.945–3.688)

0.103

Ref

1.237 (0.746–2.051)

 Model 3

 

Ref

1.456 (0.716–2.962)

1.731 (0.870–3.446)

1.678 (0.837–3.361)

0.196

Ref

1.107 (0.662–1.851)

  1. ORs with 95% CIs were calculated using Logistic regression model.
  2. Model 1: adjusted for age (continuous variable) and sex.
  3. Model 2: adjusted for variables in model 1, body mass index, current smoking, current alcohol drinking, medical history (hypertension, diabetes mellitus, dyslipidemia, stroke, heart disease), WFNS , mFS, aneurysm location and treatment modality.
  4. Model 3: adjusted for variables in model 2, plus preoperative WBC count, total cholesterol, triglyceride, high-density lipoprotein, and low-density lipoprotein.
  5. Bold indicate statistical significance.
  6. WFNS World Federation of Neurological Societies Scale; mFS modified Fisher Scale; WBC white blood cell; mRS modified Rankin Scale.
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