Fig. 6 | Scientific Reports

Fig. 6

From: Exosomes derived from hypoxic mesenchymal stem cell ameliorate premature ovarian insufficiency by reducing mitochondrial oxidative stress

Fig. 6

HExos inhibited CTX-induced oxidative stress than NExos in KGN cells. (A) Detection of ROS levels in different groups by immunofluorescence staining (Scale bar = 50 μm). (B) Laser confocal microscopic images of cells treated with a JC-1 fluorescent probe and JC-1 aggregates (red) and JC-1 monomers (green). Detection of mRNA levels of SOD2 (C), SIRT3 (D), PGC1-a (E), and TFAM (F) in the ovary of rats in different groups. Three distinct experiments were evaluated via Student’s t-test, with error bars illustrated as means ± SEM (*p < 0.05, **p < 0.01, ***p < 0.001).

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