Fig. 7 | Scientific Reports

Fig. 7

From: Exosomes derived from hypoxic mesenchymal stem cell ameliorate premature ovarian insufficiency by reducing mitochondrial oxidative stress

Fig. 7

NExos and HExos regulate mitochondrial function and oxidative stress through the SIRT3/PGC-1α signaling pathway. (A) The expression of SIRT3, SOD2, PGC1a and TFAM in KGN cells was detected by RT-qPCR. (B) The ROS levels were detected by flow cytometry. (C) Flow cytometry analysis quantified changes in MMP across experimental groups. Three distinct experiments were evaluated via Student’s t-test, with error bars illustrated as means ± SEM (*p < 0.05, **p < 0.01, ***p < 0.001).

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