Table 1 Mixed-meal tolerance test (MMTT) was performed (a) after the improvement of glycemic control. MMTT was performed with 2250 mg daily of metformin, 150 mg daily of miglitol, 5 mg daily of dapagliflozin, 25 mg daily of alogliptin and 16 units/day of insulin glargine. Insulin glargine was given in the morning. Abbreviation: CPR, C-peptide immunoreactivity. < 0.2* mg/dl: less than sensitivity. (b) 3 days after dulaglutide administration. MMTT was performed in 3 days after 25 mg daily of alogliptin was changed to 0.75 mg weekly of dulaglutide, leaving the other antidiabetic drugs and insulin glargine unchanged.

From: Insights into GLP-1 and insulin secretion mechanisms in pasireotide-induced hyperglycemia highlight effectiveness of Gs-targeting diabetes treatment