Fig. 2 | Scientific Reports

Fig. 2

From: Predicting immunotherapy prognosis and targeted therapy sensitivity of colon cancer based on a CAF-related molecular signature

Fig. 2

Functional enrichment analysis of CAF hub genes and construction the CAFscore. (A,B) Scatter plots were used to visualize the Module Membership (MM) and Gene Significance (GS) of genes within the turquoise module. (C) Venn diagram showing 244 intersectional CAF hub genes. (D,E) The bubble diagram showed the GO enriched analyzes of the biological process (BP), cellular component (CC), and molecular function (MF) terms (D), and KEGG pathway analysis (E) of these 244 genes. (F) Univariate Cox analysis was conducted to identify 11 OS-related genes in the TCGA-COAD. (G) CNV of the above 11 genes. (H) Coefficient profiles of LASSO regression analysis. (I) The adjustment parameter (lambda) was determined by calculating the partial likelihood of deviance using ten-fold cross-validation.

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