Table 1 CCD was used to optimize the PD-NLCs.
Parameter | Low (-1) | Medium (0) | High (+ 1) |
|---|---|---|---|
Independent variables | |||
X1 (% w/v) | 6 | 8 | 10 |
X2 (% w/v) | 0.5 | 0.75 | 1.5 |
X3 (min) | 10 | 20 | 30 |
Dependent variables | |||
Y1 (nm) | 159.8 ± 3.46 | 520.6 ± 11.29 | |
Y2 (%) | 40.5 ± 3.1 | 81.4 ± 7.1 | |
Zeta potential | -11.6 ± 0.26 | -32.5 ± 0.64 | |
Drug Loading | 6.59 ± 0.9 | 15.62 ± 0.9 | |
PDI | 0.13 ± 0.03 | 0.42 ± 0.61 | |
