Fig. 3 | Scientific Reports

Fig. 3

From: The c.119-123dup5bp mutation in human γC-crystallin destabilizes the protein and activates the unfolded protein response to cause highly variable cataracts

Fig. 3

Overview of RNASeq results for wild type clear (WTC), CRYGC5bpdup mutant clear (MutC), and CRYGC5bpdup mutant (MutS) lenses. (A). Volcano plot showing differentially expressed genes between WTC, MutC, and MutS lenses (log2Fold Change > 0.4 or <  − 0.4 and adjusted p < 0.05). (B). Venn diagram showing two-fold differentially expressed gens among WT, MT-Clear (MC), and MT-Severe (MS) lenses. (C). Comparison of the 50 most altered IPA canonical pathways in the WT, MT-Clear (MC), and MT-Severe (MS) mouse lenses and their activation status as reflected in the Z-score for that pathway.

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