Fig. 4 | Scientific Reports

Fig. 4

From: The c.119-123dup5bp mutation in human γC-crystallin destabilizes the protein and activates the unfolded protein response to cause highly variable cataracts

Fig. 4

Comparison of UPR related canonical pathways in wild type clear (WC), CRYGC5bpdup mutant clear (MC) and CRYGC5bpdup mutant severe (MS) lenses. Genes upregulated two-fold are analyzed. (A). IPA canonical pathways related to the UPR, autophagy, and apoptosis. (B). Number of genes in UPR related pathways and the percentage upregulated (red), downregulated (green), unchanged (grey), and not included in the dataset (clear). (C). Graphical summary of pathway activation in CRYGC5bpdup mutant severe (MS) compared to wild type clear (WC) lenses. Upstream control molecules are shown at the top of the figure, cellular processes in the middle, and endpoints at the bottom.

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