Fig. 7 | Scientific Reports

Fig. 7

From: Lysine-specific demethylase 1 (LSD1) suppresses cellular senescence by riboflavin uptake-dependent demethylation activity

Fig. 7

LSD1 suppresses cellular senescence by inhibiting the expression of Sirtuin-4 and p21. Schematic diagram of LSD1 activation by SLC52A1. SLC52A1 contributes to increased riboflavin uptake upon DNA damage, activates LSD1 by increasing FAD levels, and ultimately inhibits cellular senescence by downregulating the expression of senescence-inducing genes such as Sirtuin-4 and p21.

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