Table 1 The clinical characteristics of the training and internal testing datasets.

From: Development and validation of a scoring system to predict MASLD patients with significant hepatic fibrosis

 

Training dataset

 

Internal testing dataset

 

Item

Overall

F0/1

≥F2

P*

Overall

F0/1

≥F2

P*

pKS

n (%)

660

408 (61.8)

252 (38.2)

 

131

84 (64.1)

47 (35.9)

 

1.000

Age, years

38.00 [27.00, 53.00]

34.50 [24.00, 48.00]

47.00 [31.00, 58.00]

< 0.001

35.00 [25.50, 48.50]

33.50 [25.00, 43.25]

39.00 [27.50, 52.05]

0.053

0.170

Male (%)

265 (40.2)

161 (39.5)

104 (41.3)

0.705

54 (41.2)

33 (39.3)

21(44.7)

0.677

1.000

Race (%)

   

0.012

   

0.149

< 0.001

White

361 (54.7)

204 (50.0)

157 (62.3)

 

55 (42.0)

30 (35.7)

25 (53.2)

  

Black

13 (2.0)

7 (1.7)

6 (2.4)

 

4 (3.1)

4 (4.8)

0 (0.0)

  

Asian

238 (36.0)

164 (40.2)

74 (29.4)

 

65 (49.6)

45 (53.6)

20 (42.6)

  

Other

48 (7.3)

33 (8.1)

15 (6.0)

 

7 (5.3)

5 (6.0)

2 (4.3)

  

BMI, kg/m2

35.17 [30.68, 39.59]

35.25 [30.59, 39.46]

35.09 [30.92, 39.69]

0.985

35.20 [30.82, 41.45]

35.21 [30.89, 41.69]

35.20 [30.60, 40.62]

0.943

0.600

Diabetes (%)

226 (34.2)

97 (23.8)

129 (51.2)

< 0.001

47 (35.9)

20 (23.8)

27 (57.4)

< 0.001

1.000

HBA1C, %

5.80 [5.40, 6.50]

5.70 [5.30, 6.10]

6.00 [5.50, 7.06]

< 0.001

5.80 [5.40, 6.55]

5.70 [5.30, 6.32]

6.30 [5.80, 6.90]

< 0.001

0.427

WBC, ×109/L

7.20 [6.03, 8.71]

7.28 [6.20, 8.79]

7.03 [5.90, 8.65]

0.062

7.30 [6.05, 8.86]

7.75 [6.23, 8.93]

6.73 [5.82, 7.75]

0.057

0.767

HGB, g/L

142.00 [133.00, 152.00]

141.40 [133.00, 152.00]

143.00 [134.00, 153.00]

0.714

143.00 [132.00, 154.00]

140.00 [130.10, 152.80]

147.00 [135.50, 156.00]

0.055

0.941

PLT, ×109/L

261.00 [217.00, 307.25]

271.00 [231.00, 311.18]

239.55 [191.75, 294.05]

< 0.001

262.00 [218.50, 316.60]

282.50 [223.50, 332.80]

254.00 [188.5.00, 287.50]

0.019

0.557

CREA, µmol/L

70.00 [56.77, 79.56]

67.45 [55.72, 79.56]

70.72 [61.66, 79.67]

0.038

70.00 [53.04, 79.56]

70.36 [53.04, 79.56]

70.00 [58.70, 79.56]

0.42

0.973

BUN, mmol/L

4.28 [3.57, 5.14]

4.28 [3.57, 5.00]

4.34 [3.57, 5.29]

0.208

4.29 [3.85, 5.33]

4.28 [3.78, 5.00]

4.36 [3.88, 5.54]

0.536

0.343

TBIL, µmol/L

11.20 [8.55, 15.17]

10.80 [8.28, 13.83]

11.97 [8.55, 15.39]

0.051

10.26 [8.25, 15.35]

10.03 [8.28, 14.10]

10.80 [8.15, 15.39]

0.594

0.458

DBIL, µmol/L

1.71 [1.71, 3.42]

1.71 [1.71, 3.42]

1.95 [1.71, 3.42]

0.160

1.71 [1.71, 3.42]

1.71 [1.71, 3.05]

2.20 [1.71, 3.46]

0.212

0.887

ALT, U/L

57.00 [35.00, 90.00]

50.50 [31.00, 81.00]

68.00 [45.75, 106.50]

< 0.001

56.00 [32.00, 85.00]

49.00 [28.00, 65.50]

81.00 [49.50, 142.50]

< 0.001

0.659

AST, U/L

39.00 [26.00, 59.00]

32.00 [22.00, 47.25]

51.00 [35.00, 75.00]

< 0.001

37.00 [26.00, 54.00]

31.50 [22.00, 41.00]

54.00 [36.50, 80.00]

< 0.001

0.582

AAR

0.70 [0.54, 0.89]

0.66 [0.54, 0.83]

0.76 [0.58, 0.98]

< 0.001

0.67 [0.54, 0.83]

0.69 [0.57, 0.84]

0.64 [0.50, 0.81]

0.343

0.389

APR

0.15 [0.10, 0.25]

0.12 [0.08, 0.19]

0.23 [0.14, 0.37]

< 0.001

0.14 [0.10, 0.22]

0.11 [0.08, 0.16]

0.23 [0.15, 0.35]

< 0.001

0.824

ALP, U/L

84.00 [69.00, 111.00]

82.00 [67.00, 105.00]

88.50 [72.00, 115.25]

0.007

88.00 [71.00, 110.00]

85.50 [71.00, 109.25]

94.00 [73.50, 112.50]

0.415

0.726

GGT, U/L

44.00 [27.00, 81.25]

33.00 [23.00, 60.25]

64.00 [40.75, 105.00]

< 0.001

43.00 [28.00, 75.00]

33.50 [26.00, 52.70]

62.00 [43.00, 95.50]

< 0.001

0.660

TP, g/L

72.00 [68.30, 76.00]

72.00 [68.00, 75.00]

73.45 [70.00, 76.90]

< 0.001

72.20 [68.05, 75.85]

72.00 [68.00, 74.80]

73.00 [68.90, 77.30]

0.009

0.905

ALB, g/L

42.30 [40.00, 45.00]

42.40 [40.38, 45.00]

42.00 [39.00, 45.00]

0.400

42.6 [40.00, 45.00]

42.00 [39.73, 44.00]

44.00 [40.10, 45.80]

0.019

0.952

GLB, g/L

29.90 [26.49, 33.00]

29.00 [26.00, 32.00]

31.00 [27.60, 34.00]

< 0.001

30.00 [26.40, 33.00]

29.20 [26.08, 33.00]

30.00 [26.75, 33.25]

0.703

1.000

GTR

0.41 [0.38, 0.44]

0.40 [0.38, 0.43]

0.42 [0.39, 0.45]

< 0.001

0.41 [0.38, 0.44]

0.42 [0.38, 0.44]

0.41 [0.38, 0.44]

0.434

0.994

UA, µmol/L

369.20 [309.40, 448.35]

380.80 [309.40, 448.35]

362.95 [307.91, 448.35]

0.490

397.00 [334.90, 478.80]

388.10 [339.10, 466.40]

410.00 [307.20, 504.70]

0.644

0.088

TG, mmol/L

1.62 [1.20, 2.35]

1.60 [1.16, 2.26]

1.69 [1.24, 2.48]

0.127

1.64 [1.22, 2.34]

1.53 [1.10, 2.11]

2.09 [1.46, 2.63]

0.001

0.650

TC, mmol/L

4.94 [4.34, 5.73]

4.95 [4.39, 5.73]

4.91 [4.21, 5.71]

0.252

5.06 [4.30, 5.72]

4.98 [4.29, 5.56]

5.28 [4.41, 6.25]

0.188

0.589

HDL, mmol/L

1.03 [0.90, 1.21]

1.06 [0.91, 1.22]

0.98 [0.88, 1.19]

0.043

1.04 [0.93, 1.25]

1.06 [0.96, 1.27]

1.01 [0.92, 1.17]

0.202

0.132

LDL, mmol/L

3.03 [2.48, 3.63]

3.04 [2.53, 3.62]

3.00 [2.33, 3.65]

0.252

3.07 [2.53, 3.16]

3.04 [2.59, 3.48]

3.16 [2.46, 3.96]

0.227

0.871

  1. The data were shown as median [interquartile range] or n (%). P*, p-value for comparison between F0/1 and ≥ F2 within the same dataset. PKS, p-value for Kolmogorov-Smirnov (KS) test; BMI, body mass index; HbA1c, hemoglobin A1c; WBC, white blood cell; HGB, hemoglobin; PLT, platelets; CREA, creatinine; BUN, blood urea nitrogen; TBIL, total bilirubin; DBIL, direct bilirubin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AAR, AST/ ALT ratio; APR, AST/ PLT ratio; GGT, gamma glutamyl- transpeptidase; ALP, alkaline phosphatase; TP, total protein; ALB, albumin; GLB, globulin; GTR, GLB/ TP ratio; UA, uric acid; TG, triglyceride; TC, total cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein.
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