Table 2 The clinical characteristics of the external testing datasets.

From: Development and validation of a scoring system to predict MASLD patients with significant hepatic fibrosis

 

External testing 1#

 

External testing 2#

Item

Overall

F0/1

≥F2

P*

Overall

F0/1

≥F2

P*

n

280

112 (40.0)

168 (60.0)

 

84

36 (42.9)

48 (57.1)

 

Age, years

53.00 [43.00, 60.00]

51.00 [40.00, 59.00]

54.00 [46.00, 60.00]

0.024

34.00 [27.75,44.00]

32.50 [28.00,36.00]

37.50 [27.75,50.00]

0.025

Male (%)

96 (34.3)

47 (42.0)

49 (29.2)

0.037

47 (56.0)

20 (55.6)

27 (56.2)

1

Race (%)

   

0.004

   

-

White

244 (87.1)

91 (81.2)

153 (91.1)

 

-

-

-

 

Black

7 (2.5)

2 (1.8)

5 (3.0)

 

-

-

-

 

Asian

16 (5.7)

13 (11.6)

3 (1.8)

 

84 (100.0)

36 (42.9)

48 (57.1)

 

Other

13 (4.6)

6 (5.4)

7 (4.2)

 

-

-

-

 

BMI, kg/m2

33.58 [30.26, 37.58]

32.63 [29.63, 35.69]

34.28 [30.87, 39.02]

0.003

27.90 [25.07,33.03]

28.50 [25.58,34.02]

27.73 [24.85,32.44]

0.282

Diabetes (%)

149 (53.2)

42 (37.5)

107 (63.7)

< 0.001

17 (20.2)

3 (8.3)

14 (29.2)

0.038

HBA1C, %

6.20 [5.70, 7.00]

6.00 [5.60, 6.53]

6.40 [5.97, 7.30]

< 0.001

5.80 [5.55,6.60]

5.70 [5.53,5.88]

6.40 [5.70,7.10]

0.019

WBC, ×109/L

6.90 [5.60, 8.33]

6.55 [5.47, 7.90]

7.15 [5.70, 8.60]

0.035

7.06 [5.79,8.23]

7.30 [6.02,8.53]

6.92 [5.72,8.06]

0.191

HGB, g/L

140.00 [130.80, 148.00]

142.00 [132.00, 151.00]

139.00 [130.00, 147.20]

0.062

146.00 [132.00,156.00]

144.30 [133.00,155.10]

146.50 [130.75,156.25]

0.964

PLT, ×109/L

232.50 [197.00, 275.25]

242.00 [203.75, 287.00]

224.50 [188.00, 267.00]

0.02

258.50 [210.70,298.00]

258.00 [236.60,305.00]

259.50 [204.00,290.25]

0.043

CREA, µmol/L

70.72 [61.88, 79.56]

70.72 [61.88, 88.40]

70.72 [53.04, 79.56]

0.022

67.00 [55.50,76.00]

69.00 [59.38,76.00]

65.00 [54.10,76.10]

0.195

BUN, mmol/L

4.82 [3.93, 5.71]

5.00 [4.55, 6.07]

4.64 [3.57, 5.71]

0.002

4.56 [3.89,5.40]

4.55 [3.94,5.40]

4.56 [3.87,5.42]

0.818

TBIL, µmol/L

10.26 [6.84, 13.68]

10.26 [6.84, 11.97]

10.26 [6.84, 15.39]

0.035

12.90 [9.20,17.60]

11.12 [8.40,13.15]

14.95 [11.07,18.34]

0.006

DBIL, µmol/L

1.71 [1.71, 3.42]

1.71 [1.71, 3.42]

1.71 [1.71, 3.42]

0.064

4.00 [2.77,5.63]

3.10 [2.26,4.60]

4.70 [3.45,6.04]

0.003

ALT, U/L

67.50 [48.00, 107.25]

57.00 [45.50, 90.25]

75.00 [52.75, 119.25]

0.002

86.10 [48.42,135.80]

72.15 [38.75,127.50]

93.50 [55.00,148.18]

0.128

AST, U/L

51.00 [36.00, 74.25]

40.00 [31.00, 55.25]

58.00 [43.00, 86.50]

< 0.001

43.45 [28.00,67.00]

30.45 [23.75,51.00]

48.25 [32.50,74.17]

0.009

AAR

0.74 [0.61, 0.94]

0.66 [0.54, 0.84]

0.79 [0.66, 0.98]

< 0.001

0.57 [0.43,0.76]

0.51 [0.43,0.69]

0.60 [0.43,0.78]

0.645

APR

0.23 [0.15, 0.34]

0.17 [0.12, 0.25]

0.28 [0.19, 0.41]

< 0.001

0.16 [0.10,0.29]

0.11 [0.08,0.22]

0.21 [0.14,0.33]

0.002

ALP, U/L

76.00 [62.75, 97.00]

69.00 [56.75, 89.00]

84.50 [66.75, 101.25]

< 0.001

89.00 [76.00,108.50]

89.00 [71.75,110.00]

91.00 [77.00,108.50]

0.585

GGT, U/L

49.00 [33.00, 91.00]

38.00 [29.00, 62.25]

59.00 [37.75, 118.25]

< 0.001

64.50 [33.75,123.25]

41.00 [27.00,96.00]

74.50 [42.75,129.50]

0.022

TP, g/L

73.00 [70.00, 76.00]

73.00 [69.75, 75.25]

73.00 [70.00, 76.00]

0.272

72.95 [70.15,76.53]

72.70 [69.28,76.12]

73.10 [70.90,76.77]

0.949

ALB, g/L

43.00 [40.00, 46.00]

44.00 [41.00, 46.25]

43.00 [40.00, 45.00]

0.005

44.55 [41.20,46.73]

45.00 [41.80,46.73]

44.10 [41.00,46.73]

0.284

GLB, g/L

30.00 [27.00, 33.00]

29.00 [27.00, 31.25]

31.00 [27.00, 34.00]

0.002

29.00 [26.50,32.00]

27.51 [25.75,31.45]

29.85 [27.00,32.00]

0.172

GTR

0.41 [0.38, 0.45]

0.40 [0.37, 0.43]

0.41 [0.39, 0.46]

0.002

0.39 [0.36,0.43]

0.39 [0.35,0.43]

0.40 [0.36,0.43]

0.214

UA, µmol/L

362.95 [309.40, 422.45]

371.88 [315.35, 422.45]

354.02 [303.45, 422.45]

0.305

427.05 [351.82,512.25]

421.05 [356.92,508.85]

441.25 [340.50,512.25]

0.697

TG, mmol/L

1.79 [1.29, 2.36]

1.67 [1.25, 2.29]

1.82 [1.33, 2.39]

0.128

1.81 [1.19,2.51]

1.47 [0.93,2.21]

2.32 [1.44,3.11]

0.001

TC, mmol/L

4.84 [4.09, 5.75]

4.80 [4.12, 5.18]

4.93 [4.11, 5.85]

0.176

5.14 [4.34,5.72]

4.94 [4.28,5.68]

5.27 [4.45,5.78]

0.332

HDL, mmol/L

1.09 [0.91, 1.27]

1.07 [0.93, 1.27]

1.09 [0.88, 1.27]

0.761

1.06 [0.94,1.31]

1.09 [0.98,1.31]

1.03 [0.92,1.32]

0.340

LDL, mmol/L

2.81 [2.15, 3.52]

2.82 [2.17, 3.34]

2.79 [2.13, 3.66]

0.595

3.03 [2.42,3.60]

3.02 [2.40,3.57]

3.03 [2.43,3.66]

0.877

  1. The data were shown as median [interquartile range] or n (%). P*, p-value for comparison between F0/1 and ≥ F2 within the same external dataset. BMI, body mass index; HbA1c, hemoglobin A1c; WBC, white blood cell; HGB, hemoglobin; PLT, platelets; CREA, creatinine; BUN, blood urea nitrogen; TBIL, total bilirubin; DBIL, direct bilirubin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AAR, AST/ ALT ratio; APR, AST/ PLT ratio; GGT, gamma glutamyl- transpeptidase; ALP, alkaline phosphatase; TP, total protein; ALB, albumin; GLB, globulin; GTR, GLB/ TP ratio; UA, uric acid; TG, triglyceride; TC, total cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein.
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