Fig. 8
From: Dapagliflozin inhibits ferroptosis and ameliorates renal fibrosis in diabetic C57BL/6J mice
Network pharmacology and macromolecular docking. (a) A Venn diagram. (b) PPI Network. (c) The visualization results of the PPI network diagram. (d) The top 10 core targets. (e) The mRNA levels of TNF. (f) The mRNA levels of TP53. (g) The mRNA levels of CASP3. (h) The mRNA levels of STAT3. (i) The mRNA levels of MTOR. (j) The mRNA levels of NFE2L2. (k) The mRNA levels of PTGS2. (l) The mRNA levels of RELA. (m) The mRNA levels of SRC. (n) The mRNA levels of ESR1. (o) GO analysis by three-tier dependency circle diagram. (p) GO analysis by double X-axis bar and line chart. (q) KEEG analysis. (r) The “drug-target-pathway-disease” network diagram. (s) The molecular docking result of PTSG2 with DAPA. (t) The molecular docking result of SRC with DAPA. (u) The molecular docking result of NEF2L2 with DAPA. (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, #p < 0.05, ##p < 0.01, ###p < 0.001, ####p < 0.0001).
