Fig. 7 | Scientific Reports

Fig. 7

From: Exploring the active ingredients and potential mechanisms of Pingchan granules in Parkinson’s disease treatment through network pharmacology and transcriptomics

Fig. 7

Cellular Expression and Functional Insights of Hub Drug Target Genes in the Midbrain (a) Uniform Manifold Approximation and Projection (UMAP) plot delineating 12 distinct cell clusters (b) Violin plot illustrating the distribution of the 10 hub drug target genes across the 12 different cell types. (c) Expression patterns of hub drug targets within various cell types. Gene Set Enrichment Analysis (GSEA) of the SLC6A3 single gene in dopaminergic neurons revealed significant alterations in: (d) Glycolysis/Gluconeogenesis Pathway, (e) Mitophagy Pathway, and (f) Synaptic Vesicle Recycling. Similarly, single-gene GSEA analysis on SRC in dopaminergic neurons uncovered changes in: (g) Pentose Phosphate Pathway, (h) Phosphoinositide Metabolism, and (i) NF-Kappa B Signaling Pathway.

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