Fig. 3
From: Glaucocalyxin A alleviates ulcerative colitis by inhibiting PI3K/AKT/mTOR signaling
Identification of candidate targets for GLA against IBD. (A) Venn plot showing the intersection of GLA and IBD-related genes. (B) Protein-protein interaction (PPI) networks. The nodes represent proteins, and the edges represent the interactions between proteins. The size and shade of color of a node are directly proportional to its connectivity, with nodes with higher connectivity appearing larger and darker in color. (C) Sub-networks of important hub genes in the PPI network. These central hub genes may play an important role in the pathophysiology of IBD. (D) Gene-disease association networks. The yellow triangles represent the common targets, and the pink nodes represent the signaling pathways associated with them. (E) Functional enrichment analysis of common targets. (F) KEGG pathway enrichment analysis. The bubble map shows the significantly enriched pathways, and the size and color of the bubbles indicate the number of enriched genes and significance of the difference, respectively, thus revealing the underlying biological pathways. Docking conformation of GLA to key target proteins. (G) GLA with AKT. (H) GLA with PI3K.
