Fig. 2

Effects of DMT on mouse atrial preparations. (A) Original recording: Effect of DMT and serotonin on force of contraction in an isolated paced (1 Hz) left atrial preparation of a 5-HT₄ receptor overexpressing mouse (5-HT₄-TG). At the end of the concentration response curve for DMT (CRC), serotonin (5-HT) was applied. Then washout was performed and again DMT was given (2nd CRC). Horizontal bar: time axis in minutes (min). Vertical bar: developed tension in milli Newton (mN). (B) Summarized effects of DMT and serotonin on force of contraction in isolated electrically driven (1 Hz) left atria of 5-HT₄-TG mice. (C) Summarized effects of DMT and serotonin on the beating rate in isolated spontaneously beating right atria of 5-HT₄-TG mice. (D) Summarized effects of DMT on time to peak tension (TTP) and time of relaxation (TR) in left atria of 5-HT₄-TG mice. *First significant difference (p < 0.05) versus control (Ctr, predrug value); ^#First significant difference (p < 0.05) versus 10 µM DMT. Numbers in brackets indicate number of experiments.