Fig. 4 | Scientific Reports

Fig. 4

From: Cardiac effects of two hallucinogenic natural products, N,N-dimethyl-tryptamine and 5-methoxy-N,N-dimethyl-tryptamine

Fig. 4

Time-dependent increase of force of contraction in isolated electrically stimulated (1 Hz) left atria of 5-HT4-TG mice. (A) Time-dependent effect of 10 µM DMT, (B) of 3 µM 5-MeO-DMT, and (C) of 10 nM serotonin (5-HT). At the specified drug concentrations, the developed force of contraction was expressed as delta force normalized to the maximum effect. The time to reach the half maximum effect (tmax½) is provided below the corresponding graph, along with the 95% confidence interval (CI). *p < 0.05 versus control (Ctr, predrug value). Numbers in brackets indicate number of experiments.

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