Table 1 ICD-related genes.

From: Immunogenic cell death signature predicts survival and reveals the role of VEGFA + Mast cells in lung adenocarcinoma

Gene	Description	Role	References
PDIA3	Promotes the uptake of dead cell-associated antigens	Active	^5,6,8,44
HMGB1	Promotes the synthesis of pro-inflammatory factors including type I IFNs	Active	^5,6,7,8,44
AGER	PRR of HMGB1	Active	^6,7,8
TLR2	PRR of HMGB1	Active	^6,8
TLR4	PRR of HMGB1	Active	^5,6,7,8,44
MYD88	Part of TLR4 signaling systems	Active	^7,8,44
LY96	Part of TLR5 signaling systems	Active	⁴⁴
HSPA1A	Stimulates the uptake of dead cell-associated antigens	Active	^5,6,7,8,44
HSP90AA1	Stimulates the uptake of dead cell-associated antigens	Active	^5,6,7,8,44
ANXA1	Guides the final approach of APCs to dying cells	Active	^5,6,7,8
FPR1	PRR of ANXA1	Active	^5,6,7,8
P2RX7	Purinergic receptor	Active	^5,6,7,8,44
P2RY2	Purinergic receptor	ACTIVE	^5,6,7,8
NT5E	The ATP-degrading ectoenzyme	Inhibition	^5,6,8,44
ENTPD1	The ATP-degrading ectoenzyme	Inhibition	^5,6,7,8,44
EIF2S1	eIF2αphosphorylation correlates with CALR exposure and tumor infiltration by DCs and CTLs	Active	^5,6,7,8
EIF2AK3	eIF2αphosphorylase	Active	^5,6,7,44
CALR	Promotes the uptake of dead cell-associated antigens	Active	^5,6,7,8,44
LRP1	PRR of CALR	Active	^5,6,8
CD47	As anti-phagocytic signals that antagonize CALR	Inhibition	^5,6,7,8
CASP8	ICD-associated exposure of CALR	Active	^6,7,8
ERN1	ICD-associated exposure of CALR	Active	⁵
XBP1	ICD-associated exposure of CALR	Active	5
BCAP31	ICD-associated exposure of CALR	Active	^6,7
BAX	ICD-associated exposure of CALR	Active	^7,44
BAK1	ICD-associated exposure of CALR	Active	⁷
VAMP1	ICD-associated exposure of CALR	Active	^6,7
SNAP25	ICD-associated exposure of CALR	Active	^6,7
STC1	retaining CALR intracellularly	Inhibition	⁵
TLR3	PRR of RNA	Active	^5,6,7,8
ATG5	Autophagy	Active	^8,44
ATG7	Autophagy	Active	⁸
CXCL10	Stimulates T-cell recruitment	Active	⁵
CXCR3	CXCL10 receptor	Active	^8,44
NLRP3	Mediate pro-inflammatory effects	Active	^7,8,44
CASP1	Mediate pro-inflammatory effects	Active	⁴⁴
IL1B	Mediate pro-inflammatory effects	Active	^6,7,8,44
Il17a	Mediate pro-inflammatory effects	Active	^7,8,44
Il17ra	Il17a receptor	Active	^7,8,44
PIK3CA	Ablation compromised Chemotherapy-induced ICD and Hyp-PDT induced ICD	Active	⁴⁴
IL6	High IL6 associated with enhanced ICD	Active	⁴⁴
TNF	High TNF associated with enhanced ICD	Active	⁴⁴
IL1R1	Ablation compromised ICD	Active	⁴⁴
PRF1	Ablation compromised ICD	Active	⁴⁴
FOXP3	Mediate immunosuppressive effects	Inhibition	⁴⁴
CTLA4	Mediate immunosuppressive effects	Inhibition	^5,6
IL10	Mediate immunosuppressive effects	Inhibition	^5,6,44
CD4	Depletion of these cells compromised ICD	Active	⁴⁴
CD8A	Depletion of these cells compromised ICD	Active	⁴⁴
CD8B	Depletion of these cells compromised ICD	Active	⁴⁴
CGAS	Generating type I interferons	Active	^5,6,7
STING1	generating type I interferons	Active	^5,7
IFNAR1	Type I IFNs receptor	Active	^5,6,7,8,44
IFNAR2	Type I IFNs receptor	Active	^5,6,7,8
Type I IFNs	Immunostimulatory	Active
IFNA1		Active	^5,6,7,8,44
IFNA2		Active	^5,6,7,8
IFNA4		Active	^5,6,7,8
IFNA5		Active	^5,6,7,8
IFNA6		Active	^5,6,7,8
IFNA7		Active	^5,6,7,8
IFNA8		Active	^5,6,7,8
IFNA10		Active	^5,6,7,8
IFNA13		Active	^5,6,7,8
IFNA14		Active	^5,6,7,8
IFNA16		Active	^5,6,7,8
IFNA17		Active	^5,6,7,8
IFNA21		Active	^5,6,7,8
IFNB1		Active	^5,6,7,8,44
IFNG		Active	⁴⁴

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Table 1 ICD-related genes.

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