Fig. 5
From: Gestational hyperglycaemia impacts glucose control and insulin sensitivity in mouse offspring
Endogenous glucose production and glucose clearance rates in male and female offspring during OGTT (PN95) and MMTT (PN100). Time course of EGP during OGTT/MMTT in male (A/E) and female (I/M) offspring. Time-averaged EGP values obtained from OGTT/MMTT and steady-state EGP values calculated from the curves in male (B/F) and female (J/N) offspring. The kinetic constants of OGTT/MMTT ka in male (C/G) and female (K/O) and k2 in male (D/H) and female (L/P) from the curve fit. Sample size (offspring dam): male (LF:10 10, HF:11 12, GDM:13 13), female (LF:9 10, HF:11 12, GDM:12 13). A-P: Data are presented as the mean ± SEM, with each value representing the average measurement of the individual offspring from one litter. Ordinary 1-way ANOVA analysis followed by Tukey’s multiple comparison test was used. * GDM vs. LF, + GDM vs. HF, # HF vs. LF. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
