Fig. 6
From: Gestational hyperglycaemia impacts glucose control and insulin sensitivity in mouse offspring
Peripheral and central insulin sensitivity. IS-L and IS-P for tracer OGTT (PN100)/MMTT (PN100), calculated according to the fractured equations in male (A, B, E, F) and female (C, D, G, H) offspring. Averaged Homa IR and Matsuda Index calculated from fasting glucose and fasting insulin levels during OGTT (PN100)/MMTT (PN100) in male (I, J) and female (K, L) offspring. Sample size (offspring dam): male (LF:10 10, HF:11 12, GDM:13 13), female (LF:9 10, HF:11 12, GDM:12 13). A–L: Data are presented as the mean ± SEM, with each value representing the average measurement of the individual offspring from one litter. Ordinary 1-way ANOVA analysis followed by Tukey’s multiple comparison test was used. * GDM vs. LF, + GDM vs. HF, # HF vs. LF. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
