Table 2 Univariate Cox analysis of original and PSM cohorts.

From: TNMpBC-NeoBCSS model: a breast cancer specific survival prediction model for triple-negative metaplastic breast carcinoma patients with neoadjuvant therapy

 

Original cohort

 

PSM cohort

 

Characteristics

HR (95% CI)

P value

HR (95% CI)

P value

Year

 

0.11

 

0.052

2007–2015

Reference

 

Reference

 

2016–2023

0.77(0.56,1.06)

 

0.60(0.36,1.01)

 

Age

 

0.03

 

0.02

< 40

Reference

 

Reference

 

40–65

1.49(0.75,2.94)

 

2.65(0.82,8.49)

 

> 65

2.04(1.03,4.06)

 

4.23(1.25,14.32)

 

Marital status

 

0.008

 

0.30

Married

Reference

 

Reference

 

Others a

1.45(1.09,1.91)

 

1.41(0.88,2.26)

 

Unknown

0.45(0.14,1.42)

 

0.60(0.08,4.38)

 

Race

 

0.20

 

0.20

White

Reference

 

Reference

 

Black

1.36(0.95,1.94)

 

0.94(0.48,1.87)

 

Others b

0.90(0.55,1.47)

 

1.65(0.89,3.05)

 

Primary Site

 

0.007

 

0.18

Inner

Reference

 

Reference

 

Outer

1.37(0.90,2.09)

 

1.82(0.88,3.74)

 

Others c

1.88(1.23,2.88)

 

1.78(0.87,3.63)

 

Grade

 

0.08

 

0.23

I–II

Reference

 

Reference

 

III–IV

1.77(1.07,2.93)

 

1.64(0.70,3.80)

 

Unknown

1.63(0.88,3.01)

 

1.03(0.37,2.90)

 

T stage

 

< 0.001

 

< 0.001

T1

Reference

 

Reference

 

T2

2.06(1.28,3.33)

 

3.13(0.94,10.37)

 

T3

8.46(5.15,13.90)

 

7.67(2.29,25.72)

 

T4

13.86(8.11,23.70)

 

30.17(8.99,101.23)

 

N stage

 

< 0.001

 

< 0.001

N0

Reference

 

Reference

 

N1

2.61(1.89,3.60)

 

2.75(1.67,4.52)

 

N2

4.42(2.69,7.25)

 

6.25(2.62,14.92)

 

N3

5.56(2.45,12.64)

 

5.90(1.41,24.62)

 

Treatment d

 

< 0.001

 

< 0.001

CR

Reference

 

Reference

 

PR

9.85(1.29,74.95)

 

9.98(1.31,75.92)

 

NR

20.78(2.80,153.87)

 

19.86(2.86,147.37)

 

AT

5.32(0.71,38.01)

 

7.67(1.05,56.03)

 

Surgery

 

< 0.001

 

0.009

Mastectomy

Reference

 

Reference

 

Breast-Conserving

0.42(0.30,0.57)

 

0.39(0.20,0.77)

 

Breast-Reconstruction

0.74(0.49,1.13)

 

0.64(0.35,1.18)

 

Radiation Therapy

 

0.33

 

0.82

Yes

Reference

 

Reference

 

No/Unknown

1.15(0.87,1.51)

 

1.05(0.66,1.68)

 
  1. aIncluding Single(never married), Divorced, Separated, Unmarried or domestic partner, widowed.
  2. bIncluding Asian or Pacific Islander, American Indian/Alaska Native, Latino.
  3. cIncluding C50.0 Nipple, C50.1 Central proportion of breast, C50.6 Axillary tail of breast, C50.8 Overlapping lesion of breast, C50.9 breast, NOS.
  4. dCR: complete response; PR: partial response; NR: no response; AT, adjuvant therapy.
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