Table 3 The Anti-inflammatory activity (R.B.C. Membrane stabilization %) and antioxidant activities (free radical scavenging %) of the synthesized compounds.

From: Synthesis, antimicrobial, anti-inflammatory, antioxidant and cytotoxicity of new pyrimidine and pyrimidopyrimidine derivatives

Compound

R.B.Cs membrane stabilization (%)

Free Radical Scavenging (%)

1a

34.09 ± 0.87

22.10 ± 0.74

1b

22.50 ± 1.35

14.54 ± 0.97

1c

30.08 ± 2.01

11.85 ± 0.41

1d

35.27 ± 1.48

41. 75 ± 1.56

2a

58.91 ± 0.83

51.28 ± 1.22

2b

56.33 ± 1.28

50.03 ± 1.79

2c

63.20 ± 0.57

60.38 ± 1.85

2d

39.42 ± 1.23

18.52 ± 0.29

3a

50.86 ± 0.92

34.50 ± 0.51

3b

58.78 ± 1.61

38.97 ± 0.67

3c

61.24 ± 2.12

40.54 ± 1.30

3d

44.75 ± 1.65

36.18 ± 1.07

4a

64.82 ± 1.77

61.02 ± 1.16

4b

69.33 ± 1.42

71.34 ± 0.86

4c

65.74 ± 1.33

53.42 ± 0.73

4d

60.05 ± 2.24

49.31 ± 0.68

5a

45.89 ± 1.90

39.75 ± 0.92

5b

52.35 ± 1.18

48.11 ± 0.64

5c

57.20 ± 0.86

40.99 ± 0.81

5d

60.19 ± 1.65

42.15 ± 0.75

6a

18.50 ± 0.34

11.40 ± 0.48

6b

32.40 ± 0.82

9.66 ± 0.58

6c

24.18 ± 0.71

8.22 ± 0.34

6d

18.92 ± 0.43

10.36 ± 0.59

7a

66.85 ± 0.75

54.19 ± 1.26

7b

64.28 ± 1.83

58.48 ± 0.96

7c

51.24 ± 1.37

48.62 ± 1.17

7d

58.70 ± 0.42

52.33 ± 0.72

8a

32.44 ± 0.76

36.75 ± 0.83

8b

57.31 ± 1.18

44.32 ± 1.08

8c

50.04 ± 1.66

42.88 ± 0.73

8d

48.44 ± 1.07

43.05 ± 0.79

9a

51.28 ± 1.39

45.02 ± 1.31

9b

30.51 ± 0.77

14.46 ± 0.34

9c

28.13 ± 0.53

18.23 ± 0.78

9d

63.42 ± 0.80

55.24 ± 1.37

10a

55.83 ± 0.46

50.98 ± 0.66

10b

52.37 ± 0.94

46.75 ± 0.49

10c

72.62 ± 2.01

77.56 ± 1.80

11a

70.05 ± 1.90

69.86 ± 1.33

11b

69.38 ± 1.70

70.15 ± 0.84

11c

67.32 ± 1.44

66.17 ± 1.19

Reference drugs

Aspirin (acetylsalicylic acid)

76.33 ± 1.89

Ascorbic acid

81.36 ± 1.72