Fig. 6

Study protocol. Black arrows: time of first hemodynamic recordings of blood pressure, heart rate, cardiac output and oxygen saturation level—and then every 5 min from baseline through the bleeding period (60 min max.) and every 20 min during follow-up; Red arrows: time of withdrawal of blood samples; Upward pointing Blue arrows labeled “PKC-ε": time of PKC-ε activator administration (5 min after bleeding initiation); Downward pointing blue arrows: time of administration of 100 ml Ringer Lactate IV (at the end of bleeding).