Fig. 4
Cytoskeleton reorganization of endothelial cells through paracrine signalling or by contact with cancer cell. (a) control endothelial cells: the integrity of the endothelium is ensured by the actin cytoskeleton network and intercellular junctions (clusters) that connect neighboring cells53,63. Some actin fibers cross the cytoplasm and some fibers connect with intercellular junctions52. (b) Under paracrine signalling, the intercellular junctions are disrupted and fibers disconnected from junctions56. (c) Physical contact between cancer cells and endothelial cells bring major modifications of the actin cytoskeleton56.
